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Título : Efficacy of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou: A test-negative case-control real-world study
Autor : Li, Xiao-ning
Huang, Yong
Wang, Wen
Jin, Qin-Long
Zhang, Chun-Huan
Qin, Peng-Zhe
Guan, Wei-Jie
Gan, Lin
Li, Yi-Lang
Liu, Wen-Hui
Dong, Hang
Miao, Yu-Tian
Fan, Shu-Jun
Zhang, Zhou-Bin
Zhong, Nan-Shan
Palabras clave : vacunas
vaccines
eficacia
vacunas de virus inactivado
SARS-Cov-2 variante Delta
China National Biotec Group (CNBG)
Sinovac
CoronaVac
Sinopharm
desarrollo clínico
Fecha de publicación : 14-Aug-2021
Editorial : Taylor & Francis
Citación : Emerging Microbes & Infections, Published online: 14 Aug 2021
Resumen : The efficacy of inactivated SARS-CoV-2 vaccines against the Delta variant, which has been associated with greater transmissibility and virulence, remains unclear. We conducted a test-negative case-­control study to explore the vaccine efficacy (VE) in real-world settings. We recruited participants aged 18-59 years who consisted of SARS-CoV-2 test-positive cases (n=74) and test-negative controls (n=292) during the outbreak of the Delta variant in May 2021 in Guangzhou city, China. Vaccination status was compared to estimate the VE of SARS-CoV-2 inactivated vaccines. A single dose of inactivated SARS-CoV-2 vaccine yielded the VE of only 13.8%. After adjusting for age and sex, the overall VE for two-dose vaccination was 59.0% (95% confidence interval: 16.0% to 81.6%) against coronavirus disease 2019 (COVID-19) and 70.2% (95% confidence interval: 29.6% to 89.3%) against moderate COVID-19 and 100% against severe COVID-19 which might overestimate due to the small sample size. The VE of two-dose vaccination against COVID-19 reached 72.5% among participants aged 40-59 years, and was higher in females than in males against COVID-19 and moderate diseases. While single dose vaccination was not sufficiently protective, the two-dose dosing scheme of the inactivated vaccines was effective against the Delta variant infection in real-world settings, with the estimated efficacy exceeding the World Health Organization minimal threshold of 50%.
URI : https://doi.org/10.1080/22221751.2021.1969291
https://observatoriovacunascovid19.unam.mx/jspui/jspui/handle/123456789/15
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